Frequent mutations in the BIRC3 gene promote metastatic potential of nasopharyngeal carcinoma cells through the TRAF2-NF-κB pathway.

doi:10.1016/j.cellsig.2026.112814

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Article

Frequent mutations in the BIRC3 gene promote metastatic potential of nasopharyngeal carcinoma cells through the TRAF2-NF-κB pathway.

Cellular signalling - 1 Dec 2026

Liu Xue, Liu Yuping, Zhu Biyun, Huang Yujuan, Chen Yong, Li Qiuyun, Deng Yayan, Huang Lihong, Cai Binli, Fan Qianqing, Luo Wenhui, Ye Jiaxiang, Li Yongqiang, Wei Jiazhang, Zhang Jinyan

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is a head and neck cancer characterized by highly locoregionally invasive behavior attributable to the latent infection with Epstein-Barr virus (EBV) and genomic instability. It is well established that EBV-encoded oncogenic molecules actively contribute to the malignant behavior of NPC cells. However, the mechanism by which aberrant genomic alterations enable NPC cells to become...

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Topics

Humans
NF-kappa B
Baculoviral IAP Repeat-Containing 3 Protein
Nasopharyngeal Carcinoma
Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Signal Transduction

TNF Receptor-Associated Factor 2

Nasopharyngeal Neoplasms

Mutation

Cell Movement

Neoplasm Metastasis

Cell Proliferation

Apoptosis

Neoplasm Invasiveness

Source

Open in PubMed

Identifiers

PMID: 42580648
DOI: 10.1016/j.cellsig.2026.112814

Genes

TRAF2

Variants

Provenance

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