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Article

Multi-omics identification of ZFPM2 and CD44 as key candidates for testicular size in sheep.

Theriogenology - 1 Dec 2026

Liu Yangkai, Chen Jialei, Song Yali, Pei Shengwei, Zhu Yuanjun, Chang Ying, Yue Xiangpeng

Abstract excerpt

Testicular size is a key determinant of ram fertility, yet its genetic architecture in sheep remains poorly understood. Crossbred sheep exhibit substantial testicular developmental variation and serve as ideal models for screening fertility-related genes. Here, we performed whole-genome sequencing (WGS)-based genome-wide association study (GWAS) on 115 rams, including seven crossbred populations (each derived...

Read the complete abstract on PubMed

Topics

Animals
Male
Testis
Sheep
Organ Size
Polymorphism, Single Nucleotide
Hyaluronan Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Transcription Factors

DNA-Binding Proteins

Source

Identifiers

PMID: 42570473
DOI: 10.1016/j.theriogenology.2026.118128

Genes

CD44
ZFPM2
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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