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Whole-genome resequencing uncovers population structure and candidate molecular markers for litter size in hetian sheep.

BMC genomics - 6 Nov 2025

Liu Bo, Liu Shihao, Li Pengfei, Tulafu Hanikzi, Ma Yanping, Huang Juncheng, Wu Weiwei

Abstract excerpt

BACKGROUND: This study leveraged whole-genome resequencing to investigate the genetic architecture, population structure, and kinship dynamics of the Hetian sheep population. By integrating genomic data with reproductive trait analysis, we aimed to identify key candidate genes associated with litter size. The findings provide new insights into the genetic mechanisms underlying litter size and establish a...

Topics

Animals
Litter Size
Polymorphism, Single Nucleotide
Whole Genome Sequencing
Sheep
Genetics, Population
Genome-Wide Association Study
Genetic Markers
Female
Genomics
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 41199169
DOI: 10.1186/s12864-025-12168-7
PMCID: PMC12593843

Genes

CNTNAP5
GALNTL6
ANTXR1
EFNA5
SAP130
SPEF2
TRERF1
ZP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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