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Article

Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms are Not Associated With Recurrent Aphthous Stomatitis: A Case-Control Study.

International dental journal - 1 Oct 2026

Magrì Chiara, Vezzosi Alessia, Vinella Angela, Mariggiò Maria Addolorata, De Falco Domenico, Petruzzi Massimo

Abstract excerpt

OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been investigated as potential genetic factors associated with recurrent aphthous stomatitis (RAS). This study investigated whether MTHFR C677T and A1298C polymorphisms, as well as circulating homocysteine, folate, and vitamin B12 levels, are associated with RAS. MATERIALS AND METHODS: In this prospective case-control study, 55 patients...

Read the complete abstract on PubMed

Topics

Humans
Stomatitis, Aphthous
Methylenetetrahydrofolate Reductase (NADPH2)
Case-Control Studies
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vitamin B 12

Folic Acid

Prospective Studies

Homocysteine

Male

Recurrence

Adult

Polymorphism, Genetic

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42546423
DOI: 10.1016/j.identj.2026.109786
PMCID: PMC13469954

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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