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Article

Immunopathogenesis, molecular phenotyping, and host-directed interventions for severe pediatric Mycoplasma pneumoniae pneumonia in the post-pandemic era.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Zhang Fu

Abstract excerpt

Severe Mycoplasma pneumoniae pneumonia (SMPP) presents a major clinical challenge, increasingly complicated by macrolide-resistant strains (MRMP) and viral co-infections. The progression of SMPP is fundamentally driven by intricate immune-mediated mechanisms rather than direct pathogen-induced injury. Key drivers include innate immune hyperactivation, such as NLRP3 inflammasome-mediated pyroptosis, and adaptive...

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Identifiers

PMID: 42534636
DOI: 10.3389/fcimb.2026.1833802
PMCID: PMC13421442

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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