Chronic exposure to environmentally relevant diazepam alters behaviour, gut microbiome, and offspring phenotype in zebrafish (Danio rerio).

Abstract excerpt

The widespread consumption and incomplete wastewater removal of the psychoactive drug diazepam (DZP) have led to its ubiquitous presence in aquatic environments, posing profound ecological risks. While the direct toxicity of DZP is well-documented, its chronic and mechanistic impacts, particularly those concerning the gut-brain axis and intergenerational effects on offspring, remain largely unexplored. To...

Topics

• Animals
• Zebrafish
• Diazepam
• Female
• Water Pollutants, Chemical
• Gastrointestinal Microbiome