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Article

Beyond fixation: persistent genetic variation under intense selection.

Molecular biology and evolution - 1 Aug 2026

Arnold Kenneth R, Greenspan Zachary S, Robinson Ryan D, Pupo Anastasia, Chavarin Valeria V, Chang Kevin S, Cannell Corrina O, Qi Miao, Mueller Laurence D, Rose Michael R, Phillips Mark A

Abstract excerpt

Understanding how and why genetic variation is maintained under sustained selection remains a central question in evolutionary genetics. Experimental evolution shows that adaptation in sexually reproducing populations is often highly polygenic, proceeding through coordinated, genome-wide allele frequency shifts from standing variation rather than classic hard sweeps. Recent explanations emphasize highly polygenic...

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PMID: 42520401
DOI: 10.1093/molbev/msag188
PMCID: PMC13455604

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