G2019S LRRK2 Kinase Inhibition in Heterozygous Mice Avoids Lung Phenotype Observed with Inhibition of WT LRRK2.

Abstract excerpt

Gain-of-function mutations in the LRRK2 protein elevate kinase activity, and heterozygous or homozygous carriers of mutant LRRK2 have an increased risk of Parkinson's disease (PD), together suggesting that inhibition of mutant LRRK2 kinase activity may be a promising therapeutic target. Conversely, LRRK2 knockout mice and people with homozygous loss-of-function LRRK2 mutations exhibit prominent pathologic changes...

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