Article
Type-specific sensitivity versus detection breadth in HPV diagnostics: improved analytical detection of HPV16/18 by nested PCR.
Archives of virology - 20 Jul 2026
da Silva Yago Tomaz Vieira, Ferreira Larissa Alves Honorato, de Lima Gomes Samara Fontes, De Albuquerque Beatriz Helena Dantas Rodrigues, De Oliveira Maryana Thalyta Ferreira Câmara, Leite Alice Dantas, Fernandes José Veríssimo, Cobucci Ricardo Ney Oliveira, Lanza Daniel Carlos Ferreira
Abstract excerpt
Accurate detection of high-risk human papillomavirus (HPV) is central to cervical cancer screening. Current diagnostic strategies increasingly prioritize broad-spectrum assays to maximize genotype coverage. However, theoretical genotype breadth does not necessarily translate into effective sample-level detection when clinically dominant targets are present at low copy number. Here, we evaluated this analytical...
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