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Article

The genetics of primary dysmenorrhoea: a systematic review.

Reproduction & fertility - 1 Jul 2026

Heger Ella, Szabo Miriam, Reid-McCann Rachel, Lucinescu Ioana-Wilhelmina, Topbas Selcuki Nura Fitnat, Zondervan Krina T, Vincent Katy

Abstract excerpt

ABSTRACT: Dysmenorrhoea is the most common gynaecological condition in women of reproductive age. Approximately 90% of cases are primary dysmenorrhoea (PDM), which is not associated with an underlying pathology. Dysmenorrhoea can have a substantial impact on quality of life, yet current therapies do not provide adequate relief to everyone. Family history (FHx) is a known risk factor that suggests genetic...

Topics

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ESR1 gene
NGF gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 42455780
DOI: 10.1530/RAF-26-0004
PMCID: PMC13452037

Genes

NGF
ESR1
IL1A
IL1B
ZMIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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