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Article

Heterogeneity in CPAP titration across unsupervised polysomnographic phenotypes of Obstructive Sleep Apnea: a retrospective study.

Sleep medicine - 1 Nov 2026

Fang Ruichen, Yang Hangyi, Li Shuangyan, Cheng Yihong, Xu Yan, Wang Yuling, Jiang Jinnong, Zhang Bin

Abstract excerpt

OBJECTIVE: The efficacy of CPAP therapy depends on optimal titration. However, pre-titration sleep assessment is limited to the AHI, which overlooks the substantial heterogeneity of OSA. Therefore, this study applied cluster analysis to describe PSG-based OSA phenotypes and investigate their CPAP titration characteristics, aiming to inform more individualized titration strategies. METHODS: This was a...

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Identifiers

PMID: 42430934
DOI: 10.1016/j.sleep.2026.109114

Genes

CPAP

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