Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Abstract excerpt

Background: Recurrence risk in breast cancer remains heterogeneous, and conventional clinicopathological variables may not fully capture the contribution of immune-related factors. We compared multiple survival modeling strategies and evaluated whether an integrated immune-inflammatory phenotype could improve disease-free survival (DFS) stratification. Methods: This retrospective single-center study included 503...

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