Article
Translational animal model for genetic predisposition to anophthalmia/microphthalmia.
Experimental eye research - 1 Sept 2026
Henker Luan, Lanier Abbigail L, Moore Phillip A, Cao Wenqi, Peralta Juan M, Zhang Yue, Hoffman Leah, Schemera Bettine, Rynders Patricia E, Petrofski Myra, Blangero John, VandeBerg John L, Neto Rachel, Wang Xu
Abstract excerpt
Anophthalmia and microphthalmia (A/M) are severe congenital malformations that are responsible for ∼11% of childhood blindness. Despite clinical advances, approximately 70-80% of human A/M cases lack a molecular diagnosis. This study aims to characterize a spontaneous, non-syndromic model of the microphthalmia, anophthalmia, and coloboma (MAC) spectrum in the laboratory opossum (Monodelphis domestica), providing...
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