FhlA-mediated regulation of proton transport and energy transduction in Escherichia coli at acidic pH.

doi:10.1371/journal.pone.0351220

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Article

FhlA-mediated regulation of proton transport and energy transduction in Escherichia coli at acidic pH.

PloS one - 1 Jan 2026

Gevorgyan Heghine, Vassilian Anait, Poladyan Anna, Trchounian Karen

Abstract excerpt

In Escherichia coli, the FhlA acts as a transcriptional activator for fdhF, hyc and hyp operons, whose gene products constitute the formate hydrogen lyase (FHL) complexes. These complexes contribute to bioenergetic regulation by consuming intracellular protons during the conversion of formate to hydrogen gas (H2). The current study elucidates the role of the FHL complex (using fhlA mutant) in the proton transport...

Topics

Escherichia coli Proteins
Escherichia coli
Hydrogen-Ion Concentration
Protons
Energy Metabolism
Glucose
Fermentation
Membrane Potentials
Hydrogen
Formates
Glycerol
Ion Transport
Mutation
Trans-Activators

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Identifiers

PMID: 42348595
DOI: 10.1371/journal.pone.0351220
PMCID: PMC13298927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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