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Interpretable Raman phenotyping of human granulosa cells aligns with endocrine-defined ovarian status.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 15 Dec 2026

Xiong Wei, Zhao Wenjie, Wu Yu, Mao Shuran, Li Yang

Abstract excerpt

Assessment of ovarian status in in vitro fertilization (IVF) is critically reliant on systemic endocrine and morphological markers, which often lack the temporal resolution and mechanistic specificity to predict individual oocyte competence, necessitating a proximal, label-free molecular phenotype. Here, we present a high-definition, label-free Raman microspectroscopy pipeline for the non-destructive phenotyping...

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AMH gene
Granulosa Cells
Ovary
Phenotype
Spectrum Analysis, Raman

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PMID: 42335705
DOI: 10.1016/j.saa.2026.128256

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AMH

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