Article
Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.
PloS one - 1 Jan 2017
Osei Sekyere John, Amoako Daniel Gyamfi
Abstract excerpt
Resistance to fluoroquinolones (FQ) is being increasingly reported and found to be mediated by efflux pumps, plasmid-mediated quinolone resistance genes (PMQR) and mutations in gyrA, gyrB, parC and parE. However, studies reporting on FQ resistance mechanisms (FQRM), particularly in Africa, are focused mostly on Salmonella. This study used a whole-genome-based approach to describe FQRM in forty-eight clinical...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Enterobacteriaceae
- Enterobacteriaceae Infections
- Fluoroquinolones
- Genomics
- Humans
- Microbial Sensitivity Tests
- Phenotype
- South Africa