Goose astrovirus genotype 2 induces autophagy in goose renal tubular epithelial cells requiring the ERK2 signaling pathway: Pharmacological evidence for a pro-viral role of autophagy.

doi:10.1016/j.psj.2026.107225

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Article

Goose astrovirus genotype 2 induces autophagy in goose renal tubular epithelial cells requiring the ERK2 signaling pathway: Pharmacological evidence for a pro-viral role of autophagy.

Poultry science - 1 Sept 2026

Wei Feng, Yang Jing, He Dalin, Liu Guocheng, Yan Yun, Peng Peng, Zhou Jiaping, Zhang Yupei, Diao Youjiang, Tang Yi

Abstract excerpt

Goose astrovirus genotype 2 (GAstV-2) is an emerging pathogen responsible for gout in goslings, posing a serious threat to the goose breeding industry in China. Although the disease has caused significant economic losses, the mechanisms underlying GAstV-2-induced pathogenesis, particularly gout formation, remain poorly understood. In this study, we investigated the effect of GAstV-2 infection on autophagy in...

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PMID: 42314299
DOI: 10.1016/j.psj.2026.107225
PMCID: PMC13312110

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