Article
Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.
BMC cardiovascular disorders - 17 Jun 2026
Bobbio Emanuele, Caiazza Martina, Pisacane Filomena, Viscovo Immacolata, Gentile Alessandro, Monda Emanuele, De Falco Chiara, Esposito Daniela, Borrelli Felice, Losi Mariangela, Bossone Eduardo, Chen Suet Nee, Frisso Giulia, Calabrò Paolo, Esposito Giovanni, Lombardi Raffaella, Limongelli Giuseppe
Abstract excerpt
BACKGROUND: Mutations in the Four-and-a-Half LIM Domains 1 (FHL1) gene are increasingly recognized as a rare cause of inherited cardiomyopathies, often associated with skeletal myopathy and adverse cardiac outcomes. The phenotypic spectrum and clinical implications of FHL1 variants remain poorly defined. OBJECTIVE: To systematically review published cases of FHL1-related cardiomyopathy and characterize the...
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