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Article

CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.

Autoimmunity - 31 Dec 2026

Wang Rui, Jiao Yuhao, Chai Shengjun, Cai Chunmei

Abstract excerpt

Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomization (MR) using expression quantitative trait loci (eQTL) and gene set enrichment analysis (GWAS) data identified IL‑6-HT genes. In vivo validation in nonobese diabetic (NOD)...

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Genome-Wide Association Study
Hashimoto Disease
Interleukin-6
Membrane Transport Proteins
Mice, Inbred NOD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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PMID: 42283571
DOI: 10.1080/08916934.2026.2687619

Genes

CCDC77
SLC45A3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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