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Article

Evolutionary Origin of Ocular Melanoma: Associations With rs12913832 G Allele Frequency and Latitude.

Cancer medicine - 1 Jun 2026

Witzenhausen Hans, Helgadottir Hildur, Höiom Veronica, Olofsson Bagge Roger, Stålhammar Gustav

Abstract excerpt

BACKGROUND: Ocular melanoma (OM) incidence varies worldwide, but the relative impact of geographic latitude versus pigmentation genetics remains debated. We investigated whether the country-level frequency of the rs12913832 derived (G) blue-eye allele (G allele frequency), or latitude better explains international differences in OM incidence. METHODS: We performed an observational ecological study of 29 countries...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42277978
DOI: 10.1002/cam4.72038
PMCID: PMC13259966

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