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Article

Longitudinal Association of Quantitative Background Parenchymal Enhancement with Breast Cancer Risk among Women with BRCA1/2 Pathogenic Variants.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2026

Nguyen Alex A, Cohen Eric A, Ehsan Sarah, Mankowski Walter C, Barufaldi Bruno, Gillette Rhonda, Domchek Susan M, Kontos Despina, McCarthy Anne Marie

Abstract excerpt

BACKGROUND: Background parenchymal enhancement (BPE) on breast magnetic resonance imaging (MRI) is a potential biomarker for breast cancer risk, but its utility among women with BRCA1/2 pathogenic variants (PV) is unclear. METHODS: We investigated the longitudinal association of quantitative BPE measures with breast cancer risk among women with BRCA1/2 PVs. Measures included median BPE and the proportion of...

Read the complete abstract on PubMed

Topics

Humans
Female
Breast Neoplasms
Middle Aged
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

BRCA1 Protein

BRCA2 Protein

Longitudinal Studies

Risk Factors

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42268243
DOI: 10.1158/1055-9965.EPI-25-1952

Genes

BRCA1
BRCA2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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