Article
Relevance of anti-Ku antibodies in Ku-positive myositis with a necrotizing myopathy-like phenotype: a pediatric case report.
Neuromuscular disorders : NMD - 1 Jul 2026
Saito Takamasa, Shigemura Tomonari, Yamanaka Ai, Yabe Manami, Nishino Ichizo, Nakazawa Yozo
Abstract excerpt
Muscle-specific antibodies against signal recognition particle (SRP) and 3‑hydroxy-3-methylglutaryl-CoA reductase (HMGCR) are established pathogenic factors in immune-mediated necrotizing myopathy (IMNM), and their titers are generally considered to correlate with disease activity. In contrast, the relevance of anti-Ku antibodies, which are myositis-associated autoantibodies typically detected in overlap...
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