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Article

Parental but not child reports of affective lability in offspring predict conversion to bipolar disorder in youth at increased genetic risk.

Journal of affective disorders - 1 Nov 2026

Roberts G, Ratheesh A, Fullerton J M, Cignarella C, Francis E, Kamali M, Stapp E K, Ghaziuddin N, Hulvershorn L, McInnis M G, Wilcox H C, Edenberg H J, Nurnberger J I, Mitchell P B

Abstract excerpt

BACKGROUND: The identification of clinical risk factors in individuals at genetic risk of developing bipolar disorder (BD), and who subsequently go on to develop BD, may enable targeted early intervention. Affective lability has been reported to be increased in youth at familial risk of psychiatric illness, and to predict onset of BD in prospective studies. However, parent-reported and child self-reports of...

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PMID: 42248532
DOI: 10.1016/j.jad.2026.122077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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