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Article

Excess nitric oxide alters cellular pH to restrict salicylic acid movement and systemic immunity.

Science advances - 29 May 2026

Xia Fan, Liu Huazhen, Yu Keshun, Yuan Xinyu, Kachroo Aardra, Kachroo Pradeep

Abstract excerpt

Plants carrying a mutation in S-nitrosoglutathione reductase 1 (GSNOR1) accumulate high nitric oxide (NO) and exhibit impaired immunity characterized by reduced pathogen-responsive salicylic acid (SA) accumulation and failure to activate normal SA signaling. We show that this reduced SA responsiveness in gsnor1 plants arises from impaired vascular-associated movement of SA, thereby compromising systemic acquired...

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Identifiers

PMID: 42213848
DOI: 10.1126/sciadv.adz4776
PMCID: PMC13220883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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