Sub-Phenotyping of Pediatric Celiac Disease with Topological Data Analysis.

Abstract excerpt

Celiac Disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals. Its heterogeneous presentation, especially in pediatric patients, limits the effectiveness of current symptom-based classifications such as the Oslo definitions. This study proposes a framework based on Topological Data Analysis (TDA) to identify new, clinically meaningful sub-phenotypes of...

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