Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multiselective Inhibitors in NRAS-Mutated Melanoma.

doi:10.1158/0008-5472.CAN-26-1313

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Article

Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multiselective Inhibitors in NRAS-Mutated Melanoma.

Cancer research - 14 Aug 2026

Foth Mona, Kim Wontak, O'Toole Kayla, Murphy Brandon, Justo-Garrido Montserrat, Boggaram Sanjana, Ghazi Phaedra, Brennan Euan, Wright M Isaac, Shepherd Tate, Cortes-Sanchez Emilio, Wang Yingyun, Roth Jennifer A, Rees Matthew G, Ronan Melissa M, Jiang Jingjing, Wasko Urszula N, Jiang Amanda, Becker Carly, Deacon Dekker C, Holmen Sheri L, VanBrocklin Matthew W, Hu-Lieskovan Siwen, Kinsey Conan G, Russell Jeffery S, Hegde Aparna, Garrido-Laguna Ignacio, Holderfield Matthew, Singh Mallika, McMahon Martin

Abstract excerpt

Most patients with advanced BRAF- or NRAS-driven melanoma receive first-line immunotherapy. However, if immunotherapy fails, BRAF-mutated patients receive effective second-line therapies, whereas NRAS-mutated patients lack pathway-targeted options. Recently, RAS(ON) multiselective inhibitors like...

Topics

Humans
Melanoma
GTP Phosphohydrolases
Drug Resistance, Neoplasm
Mutation
Membrane Proteins
Cell Line, Tumor
Animals
MAP Kinase Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Antineoplastic Agents

Cell Proliferation

Mice

Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 42171647
DOI: 10.1158/0008-5472.CAN-26-1313
PMCID: PMC13335394

Genes

NRAS
BRAF
MAP2K1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-42171647-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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