Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women.

doi:10.1002/ajmg.b.70022

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Article

Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2026

Hong Jinkuk, DaWalt Leann Smith, Klusek Jessica, Berry-Kravis Elizabeth M, Mailick Marsha

Abstract excerpt

The present longitudinal study focuses on FMR1 premutation carrier women during midlife and early old age (n = 115). Bringing together the genetic risk factor of a family history of FXTAS and the environmental protective factor of higher education, the goal of the study was to determine how these factors potentially interact to predict self-reported FXTAS-type symptoms in women carrying the FMR1 premutation. We...

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Topics

Humans
Female
Fragile X Messenger Ribonucleoprotein 1
Middle Aged
Cognition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fragile X Syndrome

Heterozygote

Longitudinal Studies

Adult

Risk Factors

Aged

Mutation

Genetic Predisposition to Disease

Educational Status

Ataxia

Tremor

Source

Open in PubMed Open full text

Identifiers

PMID: 42167908
DOI: 10.1002/ajmg.b.70022
PMCID: PMC13656318

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women.PMID 42167908Read ↗

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