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Article

Changing landscape of 16 S-RMTase-mediated aminoglycoside resistance in clinical Klebsiella pneumoniae isolates from Chile between 1997 and 2023.

Scientific reports - 19 May 2026

Matus-Köhler Maximiliano, Rivas-Carrasco Rocío, Amsteins-Romero Luis, Quezada-Aguiluz Mario, Astorga-Ríos Francisco, Maurelia Felipe, Lima Celia A, Herrera-Chávez Néstor, Opazo-Capurro Andrés, González-Rocha Gerardo, Morales-León Felipe, Bello-Toledo Helia

Abstract excerpt

The emergence of 16S rRNA methyltransferase (16S-RMTases) poses a major therapeutic challenge, as they confer high-level resistance to all clinically relevant aminoglycosides. In Chile, data on these enzymes remain scarce. This study investigated the epidemiological distribution and genetic relatedness of Klebsiella pneumoniae strains carrying 16S-RMTase genes. Antibiotic susceptibility was assessed using the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42156909
DOI: 10.1038/s41598-026-51336-x
PMCID: PMC13388701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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