Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-guided Recall Delineates the Adult Auditory Phenotype in GJB2 p.V37I Homozygotes: High-frequency Vulnerability and Environmental Modulation.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Aug 2026

Chang Ting-Gang, Chen Yi-Ming, Chen I-Chieh, Hsu Chiann-Yi, Yen Ting-Ting

Abstract excerpt

BACKGROUND: GJB2 p.V37I is common in East Asian populations and is an established contributor to mild-to-moderate hearing loss, yet the adult auditory phenotype and its modification by environmental exposures remain incompletely defined. METHODS: We conducted a genotype-guided case-control recall study within the Taiwan Precision Medicine Initiative, enrolling 191 adults (96 p.V37I homozygotes; 95...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Audiometry, Pure-Tone
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Connexin 26

Share to Connexins

Share to Hearing Loss

Share to Homozygote

Share to Taiwan

Share to Tinnitus

Source

Open in PubMed Open full text

Identifiers

PMID: 42153671
DOI: 10.1097/MAO.0000000000004956
PMCID: PMC13348840

Genes

GJB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-guided Recall Delineates the Adult Auditory Phenotype in GJB2 p.V37I Homozygotes: High-frequency Vulnerability and Environmental Modulation.PMID 42153671Read ↗

Natural history and phenotype-genotype correlations in GJB2-related hearing loss: a systematic and comprehensive review.Semantic proximity Read ↗

GJB2 p.V37I Mutation Associated With Moderate Nonsyndromic Hearing Loss in an Adult Taiwanese Population.Semantic proximity Read ↗

The homozygous p. V37I variant of GJB2 is associated with diverse hearing phenotypesSemantic proximity Read ↗

Consensus interpretation of the Met34Thr and Val37Ile variants in <i>GJB2</i> by the ClinGen Hearing Loss Expert PanelSemantic proximity Read ↗

Genotypic and Allelic Frequencies of GJB2 Variants and Features of Hearing Phenotypes in the Chinese Population of the Dongfeng-Tongji CohortSemantic proximity Read ↗

Prevalence of p.V37I variant of GJB2 in mild or moderate hearing loss in a pediatric population and the interpretation of its pathogenicity.Semantic proximity Read ↗

Genetic Factors Contribute to the Phenotypic Variability in GJB2-Related Hearing Impairment.Semantic proximity Read ↗

Association between the p.V37I variant of GJB2 and hearing loss: a pedigree and meta-analysis.Semantic proximity Read ↗

[Clinical hearing phenotypes analysis of GJB2 gene p.V37I homozygote and compound heterozygote mutation in infants].Semantic proximity Read ↗

[Variant frequency of GJB2 c.109G>A (p.Val37Ile) in Chinese patients with hearing loss: a systematic review and Meta-analysis].Semantic proximity Read ↗

GJB2-associated hearing loss: systematic review of worldwide prevalence, genotype, and auditory phenotype.Semantic proximity Read ↗

A Phenome-Wide Comorbidity Atlas of Age-Related Hearing Loss, Speech-in-Noise Deficits, and Tinnitus: Distinguishing Causal Signals from Correlation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.