T2-FLAIR digital subtraction radiomics versus neuroradiologist visual assessment for differentiating IDH-mutant astrocytomas from other non-enhancing low-grade gliomas: An externally validated machine learning study.

Abstract excerpt

PURPOSE: Non-invasive differentiation of isocitrate dehydrogenase (IDH)-mutant, 1p/19q non-codeleted astrocytomas from other non-enhancing low-grade gliomas (LGGs) is crucial for treatment planning and prognostication, as these molecular subtypes have distinct therapeutic strategies and clinical outcomes. The conventional T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign offers high...

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