Genomic and phenotypic insights into ST164 blaNDM-1-positive Acinetobacter baumannii from intestinal colonization in China.

doi:10.1186/s12866-025-03979-5

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Article

Genomic and phenotypic insights into ST164 blaNDM-1-positive Acinetobacter baumannii from intestinal colonization in China.

BMC microbiology - 7 May 2025

Wang Kun, Zhu Weidong, Gong Lu, Yang Xiaolu, Ye Haowei, Lou Zhenghao, Yang Jie, Jiang Xiawei, Li Wei, Tao Fangfang, Xu Hao, Zheng Beiwen, Liu Wenhong

Abstract excerpt

BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a critical global threat, especially in ICUs. Yet, reports on ST164 CRAB harboring blaNDM-1 remain scarce. This study investigates two clinical CRAB isolates, L4773hy and L4796hy, derived from intestinal colonization in Hangzhou, China, focusing on their phenotypic and genomic characteristics as well as the broader transmission of ST164 A....

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Topics

Acinetobacter baumannii
beta-Lactamases
China
Acinetobacter Infections
Anti-Bacterial Agents
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Microbial Sensitivity Tests

Phylogeny

Drug Resistance, Multiple, Bacterial

Whole Genome Sequencing

Genome, Bacterial

Phenotype

Carbapenems

Intestines

Multilocus Sequence Typing

Mice

Genomics

Source

Open in PubMed Open full text

Identifiers

PMID: 40329220
DOI: 10.1186/s12866-025-03979-5
PMCID: PMC12057158

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