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Article

Electronegative electroretinography in inherited retinal disease: a systematic review of genotype-phenotype correlations.

BMC ophthalmology - 9 May 2026

Taha Ibrahim, Huraibat Khalil, Al-Labadi Liana

Abstract excerpt

BACKGROUND: The electronegative electroretinogram (ERG)-in which the dark-adapted bright-flash b-wave amplitude falls below the a-wave (b: a ratio < 1.0)-localizes dysfunction to the inner retina or photoreceptor-bipolar synapse. In inherited retinal disease (IRD), this waveform has been associated with a restricted set of genetic etiologies, but the evidence has not been systematically synthesized. OBJECTIVE: To...

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Topics

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Share to Dark Adaptation
Share to Electroretinography
Share to Eye Diseases, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42106701
DOI: 10.1186/s12886-026-04858-x
PMCID: PMC13159224

Genes

ERG
KCNV2
RS1
CABP4
CACNA1F
GPR179
GRM6
NYX
TRPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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