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Article

Natural noncoding pumilio variants retune value-coding interneurons to bias Drosophila oviposition decisions.

Science advances - 8 May 2026

Motevalli Dorsa, Alfredson Robert, Fogleman Sydney, Medrano Emmanuel, Chen Yang, Silander William I, Hige Toshihide, Stern Ulrich, Yang Chung-Hui

Abstract excerpt

How natural regulatory genetic variation creates innate biases in economic decisions through modifying circuit structure and function is rarely explored. Here, we trace this link in a simple value-based decision in Drosophila: where to oviposit. Although laboratory flies (w1118) reject sucrose for a plain option, a wild-caught African strain accepts sucrose. This decision difference maps to three African-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42102200
DOI: 10.1126/sciadv.aed1338
PMCID: PMC13155294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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