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Article

The Role of WWOX Gene Variant in Hypospadias and 46,XY Disorders of Sexual Development.

Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2026

Denkboy Ongen Yasemin, Tezcan-Unlu Havva, Unal Ufuk, Efendi-Erdem Ecem, Cecener Gulsah, Eren Erdal

Abstract excerpt

46,XY disorders of sexual development (46,XY DSD) are conditions characterized by deviations from typical male sex development, which encompasses a broad spectrum of clinical features such as hypospadias, decreased sperm production, dysgenetic testes, bifid scrotum, and the presence of a mature uterus and fallopian tubes. The WWOX gene, which has been implicated in various cancers, is also thought to play a role...

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Source

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Identifiers

PMID: 42082822
DOI: 10.1007/s43032-026-02112-9
PMCID: PMC13230315

Genes

WWOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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