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Phenotypic characterization of historical and contemporary Oropouche virus strains reveals divergent replication dynamics in multiple cell lines.

Virology - 1 Aug 2026

Lourenço Karine Lima, Campos Guilherme Rodrigues Fernandes, Galvão Tayna Manfrin, Sacchetto Lívia, Rubiato Júlia Guimarães Dias, Sanches Ana Carolina Parra, Vasilakis Nikos, Nogueira Mauricio Lacerda

Abstract excerpt

Oropouche virus (OROV), a significant public health threat in Latin America, has recently expanded beyond its endemic region by the emergence of a recombinant lineage. This study aimed to characterize the replication dynamics of a historical (BeAn19991) and two contemporary (AM0088, OROV43) OROV isolates in mammalian and mosquito cell lines. Using multi- and one-step growth curves, plaque assays, and...

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PMID: 42061271
DOI: 10.1016/j.virol.2026.110921

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