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Article

Case Report: Abnormally low hemoglobin A1c in a diabetic patient with SLC4A1 gene mutation.

Frontiers in endocrinology - 1 Jan 2026

Ye Lili, Ren Qian, Ba Tianhao, Wu Jing, Han Xueyao, Ji Linong

Abstract excerpt

Background: Hemoglobin A1c (HbA1c) is a critical biomarker used for the diagnosis and management of diabetes. However, nonglycemic genetic variations may affect the accuracy of HbA1c measurements. Methods: We presented a clinical evaluation of a type 2 diabetic patient with an SLC4A1 (solute carrier family 4 member 1) gene mutation, characterized by high blood glucose and low HbA1c, and estimated the carrier...

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Topics

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Share to Anion Exchange Protein 1, Erythrocyte
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycated Hemoglobin

Share to Mutation

Share to Spherocytosis, Hereditary

Source

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Identifiers

PMID: 42058779
DOI: 10.3389/fendo.2026.1785435
PMCID: PMC13121054

Genes

SLC4A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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