Empirical Osimertinib as a Second-Line Treatment Is a Viable Option Following First- and Second-Generation TKI Therapy With Unknown EGFR Status in Treated Non-Small Cell Lung Cancer: A Retrospective Study.

Abstract excerpt

BACKGROUND AND PURPOSE: Patients with advanced epidermal growth factor receptor (EGFR)-mutated adenocarcinoma often receive frontline first- and second-generation EGFR tyrosine kinase inhibitor (TKI) treatments in Taiwan. However, upon progression, not all patients undergo rebiopsy for molecular testing. In some cases, tumors are located in difficult-to-access areas, and some rebiopsy specimens are inadequate for...

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