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Article

Distinct immunophenotypic and clinical features of TP53-mutated acute myeloid leukemia: high CD34/CD41 expression and lower leukocyte counts.

Annals of hematology - 21 Apr 2026

Park Songyi, Kim Sang-A, Kim Sheehyun, Kim Seon Young, Lee Ji Yun, Byun Ja Min, Hwang Sang Mee, Lee Jeong-Ok, Koh Youngil, Hong Junshik, Chang Yoon Hwan, Kim Hyun Kyung, Bang Soo-Mee, Kim Inho, Yoon Sung-Soo, Shin Dong-Yeop

Abstract excerpt

This study investigates the clinical and molecular characteristics of TP53-mutated acute myeloid leukemia (AML), associated with a poor prognosis. A retrospective analysis was conducted on 336 AML patients, focusing on the distinctions between TP53-mutated and non-mutated cases. Our findings reveal that TP53 mutations are linked to a higher proportion of leukemic blasts positive for the primitive stem cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, CD34

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Share to Leukemia, Myeloid, Acute

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Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 42010164
DOI: 10.1007/s00277-026-07001-4
PMCID: PMC13095964

Genes

TP53
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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