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Article

Hallmarks of liver cancer: Therapeutic implications.

Cell - 16 Apr 2026

Llovet Josep M, Pinyol Roser, Affo Silvia, Yarchoan Mark, Gores Gregory J, Kelley Robin Kate, Lowe Scott W, Sia Daniela, Villanueva Augusto

Abstract excerpt

The hallmarks of cancer, first proposed in 2000, have since provided a unified framework for understanding the complexity of carcinogenesis. This conceptual model has profoundly influenced the treatment landscape of primary liver cancer, which includes hepatocellular carcinoma (HCC, ∼85%) and intrahepatic cholangiocarcinoma (iCCA, 10%)-malignancies with high mortality. Key hallmarks exhibited by HCC include...

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Share to Bile Duct Neoplasms
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41997132
DOI: 10.1016/j.cell.2026.03.001
PMCID: PMC13191572

Genes

BRAF
ERBB2
FGFR2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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