Article
Case Report: Pseudomonas liver abscess in a previously healthy child with homozygous pathogenic S allele variant of the SERPINA1 gene.
Frontiers in immunology - 1 Jan 2026
Thomas Sanya, D'Souza Alaric W, Alhezam Musaab, Platt Craig D, Levy Ofer
Abstract excerpt
Background: Pyogenic liver abscess is an uncommon pediatric condition, and Pseudomonas aeruginosa represents a rare causative agent in otherwise healthy children. Such infections may signal an underlying inborn error of immunity. Alpha-1 antitrypsin (A1AT), encoded by the SERPINA1 gene, is a serine protease inhibitor with key immunomodulatory functions. In mouse models, A1AT prevents degradation of the...
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