Initiation of Oral Pre-exposure Prophylaxis Associated With Changes in Genital Tract T Cell Phenotypes in Women Exposed to HIV.

doi:10.1093/infdis/jiag204

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Initiation of Oral Pre-exposure Prophylaxis Associated With Changes in Genital Tract T Cell Phenotypes in Women Exposed to HIV.

The Journal of infectious diseases - 2 Sept 2026

Warrier Lakshmi, Saito Ayumi, Graham Jessica B, Swarts Jessica L, Vick Sarah C, MacLean Finn, Potchen Nicole B, Cruz Talavera Irene, Tsegaye Adino Tesfahun, Thomas Katherine K, Chohan Bhavna H, Ngure Kenneth, Mugo Nelly, Lingappa Jairam R, Lund Jennifer M

Abstract excerpt

Oral tenofovir-based HIV-pre-exposure prophylaxis (PrEP), approved for use in preventing human immunodeficiency virus (HIV) infection, has been implicated in altering the immune landscape. We leveraged longitudinal samples from heterosexual couples with the male partner living with HIV and the female partner without HIV initiating PrEP after enrollment. Applying high parameter flow cytometry to cells from...

Read the complete abstract on PubMed

Topics

Humans
Female
Pre-Exposure Prophylaxis
HIV Infections
Anti-HIV Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Administration, Oral

CD4-Positive T-Lymphocytes

Tenofovir

Male

CD8-Positive T-Lymphocytes

Vagina

Cervix Uteri

Longitudinal Studies

Phenotype

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 41966988
DOI: 10.1093/infdis/jiag204
PMCID: PMC13502722

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation of Oral Pre-exposure Prophylaxis Associated With Changes in Genital Tract T Cell Phenotypes in Women Exposed to HIV.PMID 41966988Read ↗

Brief Report: Genital Microbiome, Inflammation, and Tenofovir Levels in Transgender Men and Cisgender Women Taking Oral PrEPSemantic proximity Read ↗

Oral Pre-exposure prophylaxis (PrEP) to prevent HIV: a systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populationsSemantic proximity Read ↗

Brief Report: Incidence of HIV in a Nationwide Cohort Receiving Pre-exposure Prophylaxis for HIV Prevention.Semantic proximity Read ↗

Experimental Evidence for HIV-Associated Phenotypic Reprogramming of CD4□ T Cells: An Exploratory Immunological StudySemantic proximity Read ↗

Elevated Numbers of HIV-Specific Poly-Functional CD8+ T Cells With Stem Cell-Like and Follicular Homing Phenotypes in HIV-Exposed Seronegative Individuals.Semantic proximity Read ↗

Immune quiescence: a model of protection against HIV infectionSemantic proximity Read ↗

Oral HIV pre-exposure prophylaxis use and resistance-associated mutations among men who have sex with men and transgender persons newly diagnosed with HIV in the Netherlands: results from the ATHENA cohort, 2018 to 2022.Semantic proximity Read ↗

High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis.Semantic proximity Read ↗

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral TherapySemantic proximity Read ↗

Tenofovir Diphosphate in Dried Blood Spots Is Strongly Associated With Viral Suppression in Individuals With Human Immunodeficiency Virus InfectionsSemantic proximity Read ↗

Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda.Semantic proximity Read ↗

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.