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Article

Acute effects of ketone monoester ingestion on monocyte phenotype and cytokine secretion in healthy humans.

American journal of physiology. Cell physiology - 1 May 2026

Marcotte-Chénard Alexis, Sandilands Roderick E, Teixeira Alexandre Abílio, McCarthy Seth F, Islam Hashim, Little Jonathan P

Abstract excerpt

Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human whole blood and monocytes ex vivo influence cytokine secretion and phenotype. Healthy adults (n = 13, age = 28 ± 7 yr) consumed a KME supplement containing (R)-3-hydroxybutyl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41954565
DOI: 10.1152/ajpcell.00058.2026

Genes

TNF
CD80

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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