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Article

Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams.

Antimicrobial agents and chemotherapy - 6 May 2026

Dorazio Ava J, Kline Ellen G, Squires Kevin M, Shah Sunish, Van Tyne Daria, Wu Janet Y, Pogue Jason M, Shields Ryan K

Abstract excerpt

Twelve pairs of baseline and post-exposure Pseudomonas aeruginosa isolates from patients treated with ceftazidime-avibactam were evaluated to define mechanisms of treatment-emergent resistance. Resistance was associated with amino acid substitutions in ampC and OXA β-lactamases, or mutations in regulatory genes conferring hyper-production of AmpC and MexAB-OprM efflux pumps. Cross-resistance was common between...

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Identifiers

PMID: 41940815
DOI: 10.1128/aac.01910-25
PMCID: PMC13148059

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