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Article

Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival.

Cell reports. Medicine - 21 Apr 2026

Wu Yifan, Jiao Zichen, Xue Jianchao, Zheng Xiaoyi, Huang Zhicheng, Wang Daoyun, Chen Peipei, Wang Tao, Chen Jian-Qun, Liang Naixin, Tang Yao, Wang Qiang, Chen Qihan

Abstract excerpt

Lung adenocarcinoma (LUAD) exhibits marked prognostic heterogeneity. Existing methylation-based prognostic models lack robustness, accuracy, or external validation, limiting their clinical utility. We develop MethPro-LUAD, a prognostic model based on eight 5-methylcytosine features, using TCGA-LUAD data (training, N = 269; testing, N = 180), and validate the model across two independent hospital cohorts (Beijing,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41928513
DOI: 10.1016/j.xcrm.2026.102727
PMCID: PMC13130642

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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