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Article

In vitro selection and characterization of resistance to pristinamycin in Mycoplasma genitalium.

Antimicrobial agents and chemotherapy - 6 May 2026

Le Roy Chloé, Guiraud Jennifer, Byambaa Otgonjargal, Balcon Carla, Gillet Léo, Jensen Jorgen S, Bébéar Cécile, Pereyre Sabine

Abstract excerpt

Pristinamycin, a streptogramin combination, is recommended as a third-line treatment for Mycoplasma genitalium infections according to European guidelines. However, the molecular mechanisms underlying pristinamycin resistance have not yet been elucidated. We investigated the in vitro development of pristinamycin-resistant M. genitalium mutants under exposure to subinhibitory concentrations of pristinamycin or...

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Identifiers

PMID: 41914618
DOI: 10.1128/aac.00094-26
PMCID: PMC13148045

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