Article
Reconsidering time from diagnosis to treatment in acute myeloid leukemia: from therapeutic urgency to biologically informed timing.
Expert review of hematology - 1 Jun 2026
Molica Matteo, De Fazio Laura, Porretto Ferdinando, Mulè Antonino, Rossi Marco, Martino Massimo, Alati Caterina
Abstract excerpt
INTRODUCTION: Acute myeloid leukemia (AML) has traditionally been considered a medical emergency requiring immediate cytotoxic therapy, a paradigm rooted in the pre-molecular era and high early mortality of untreated disease. However, modern AML management relies on cytogenetic, molecular, and next-generation sequencing (NGS) profiling to guide prognosis, transplant decisions, and targeted therapies, making time...
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