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Zfp503 haploinsufficiency causes optic nerve coloboma in mice.

Experimental eye research - 1 Jun 2026

Wong-Fortunato Jenna, Yang Benjamin, Lanoue Louise, Jacobo Lopez Antonio, Luxardi Guillaume, Kasiri Niusha, Minella Andrea, Imai Denise M, Thomasy Sara M, Ren Yuxin, Bacha Tarek, Sadegh Cameron, Boobalan Elangovan, Brooks Brian P, Lloyd Kc Kent, Leonard Brian C, Moshiri Ala

Abstract excerpt

PURPOSE: To investigate the role of Zfp503 in mammalian eye development. METHODS: Zfp503-/- and Zfp503+/- mice were successfully created through the Knockout Mouse Phenotyping Project (KOMP2), and abnormalities were noted through ophthalmic examination. Embryos were studied at E15.5. Postnatal mice were evaluated using electroretinography (ERG), fundus photography, fluorescein angiography, and optical coherence...

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Coloboma
Electroretinography
Fluorescein Angiography
Haploinsufficiency
Optic Disk

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tomography, Optical Coherence

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Identifiers

PMID: 41887347
DOI: 10.1016/j.exer.2026.110985

Genes

RPE
ZNF503
ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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