Recurrent Epidermal Growth Factor Receptor 2 (ERBB2) Mutations Drive the Pathogenesis of Multifocal Neurofibroma Variants.

Abstract excerpt

Recurrent Epidermal Growth Factor Receptor 2 (ERBB2) mutations have been recently documented in a small group of hybrid neurofibroma/schwannoma peripheral nerve sheath tumors (PNST) in patients with presumed sporadic schwannomatosis. Prompted by 2 cases of plexiform neurofibromas harboring ERBB2 hotspot mutations, but lacking germline alterations, we sought to investigate the clinicopathologic features of PNST...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Erb-b2 Receptor Tyrosine Kinases
• Share to ERBB2 gene