Evaluating the use of whole-genome sequencing and Sanger emm typing in guiding the identification and public health management of invasive group A Streptococcus clusters and outbreaks in England.

Abstract excerpt

Introduction. Sanger sequencing-based emm typing has traditionally been used in England to assess case relatedness when managing invasive group A Streptococcus (iGAS) outbreaks.Gap statement. While timely, emm typing can lack resolution. Whole-genome sequencing (WGS), offering greater strain discrimination, is increasingly used, but its comparative value for public health response has not been assessed.Aim. This...

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