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Article

Heat and hearts: An exposure-anchored computational phenotyping framework for assessing cardiovascular vulnerability during extreme heat.

Journal of biomedical informatics - 1 Jun 2026

Graffy Peter M, Barrett Benjamin W, Horton Daniel E, Allen Norrina B, Kho Abel N

Abstract excerpt

OBJECTIVE: Extreme heat is associated with increased cardiovascular vulnerability. We developed and validated a heat exposure-anchored cardiovascular vulnerability (HECV) computational phenotype for outpatient visits using longitudinal EHR data linked to high-resolution temperature. MATERIALS AND METHODS: We assembled a loyalty cohort of adult patients from a large Chicago-based health system (2017-2023) and...

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PMID: 41875960
DOI: 10.1016/j.jbi.2026.105029

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